Comparison of the Cervex-Brush alone to Cytobrush plus Cervex-Brush for detection of cervical dysplasia in women with a transformation zone type 3
| Autor: | Nichole Villeneuve, Andrew K Wills, Susan Glew, Amit Patel, Kristyn M. Manley, Katherine Hunt |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Histology Referral Dyskaryosis Cytodiagnosis Population 030209 endocrinology & metabolism Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Pregnancy Cytology medicine Humans education Cervix Early Detection of Cancer Vaginal Smears education.field_of_study Cervical screening Obstetrics business.industry General Medicine Middle Aged medicine.disease Uterine Cervical Dysplasia United Kingdom medicine.anatomical_structure Dysplasia Colposcopy 030220 oncology & carcinogenesis Liquid-based cytology Female business |
| Zdroj: | Cytopathology : official journal of the British Society for Clinical Cytology. 30(2) |
| ISSN: | 1365-2303 |
| Popis: | INTRODUCTION Twenty percent of colposcopic assessments are inadequate due to a type 3 transformation zone (TZ3). In the absence of colposcopic or histological assessment, subsequent management is guided by the referral screening test. In the UK, routine cervical screening is completed by a Cervex-Brush alone. This study examines the effectiveness of a Cytobrush in addition to a standard Cervex-Brush when used in TZ3 assessment. METHODOLOGY An 18-month diagnostic accuracy study in a single National Health Service (NHS) Trust. Women with a TZ3 booked for large loop excision of the transformation zone (LLETZ) with a referral cytology of high-risk HPV and squamous dyskaryosis were recruited. Immediately prior to LLETZ, a Cervex-Brush plus Cytobrush liquid-based cytology sample was taken. Presence of endocervical cells was compared. Predictability of high-grade cervical intra-epithelial neoplasia (CIN2+) was by blind standardised reporting of the LLETZ histology. RESULTS One hundred and five women were recruited from a total eligible population of 153 cases (68.8%). Endocervical cell yield was increased with the Cervex-Brush plus Cytobrush when compared to the Cervex-Brush alone (99.1% vs 79.1%, P |
| Databáze: | OpenAIRE |
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