Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study
| Autor: | Jose A. Martinez-Climent, C Lopéz-Capitán, M B González, T. Flores, J M Hernández, J F San Miguel, M A Piris, Juan Luis García, María D. Odero, Maria-Jose Calasanz, David Gonzalez, Norma C. Gutiérrez |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Biology Polymerase Chain Reaction Translocation Genetic law.invention Sporadic Burkitt's Lymphoma law medicine Humans Child Polymerase chain reaction Aged Chromosome Aberrations Leukemia Incidence (epidemiology) Cytogenetics Chromosome Mapping Nucleic Acid Hybridization Hematology Middle Aged Prognosis medicine.disease Burkitt Lymphoma Lymphoma Treatment Outcome Oncology Chromosomes Human Pair 1 Child Preschool Female Burkitt's lymphoma Chromosomes Human Pair 7 Comparative genomic hybridization |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Comparative genomic hybridization (CGH) studies have demonstrated a high incidence of chromosomal imbalances in non-Hodgkin's lymphoma. However, the information on the genomic imbalances in Burkitt's Lymphoma (BL) is scanty. Conventional cytogenetics was performed in 34 cases, and long-distance PCR for t(8;14) was performed in 18 cases. A total of 170 changes were present with a median of four changes per case (range 1-22). Gains of chromosomal material (143) were more frequent than amplifications (5) or losses (22). The most frequent aberrations were gains on chromosomes 12q (26%), Xq (22%), 22q (20%), 20q (17%) and 9q (15%). Losses predominantly involved chromosomes 13q (17%) and 4q (9%). High-level amplifications were present in the regions 1q23-31 (three cases), 6p12-p25 and 8p22-p23. Upon comparing BL vs Burkitt's cell leukemia (BCL), the latter had more changes (mean 4.3 ± 2.2) than BL (mean 2.7 ± 3.2). In addition, BCL cases showed more frequently gains on 8q, 9q, 14q, 20q, and 20q, 9q, 8q and 14q, as well as losses on 13q and 4q. Concerning outcome, the presence of abnormalities on 1q (ascertained either by cytogenetics or by CGH), and imbalances on 7q (P = 0.01) were associated with a short survival. This work was partially supported by Grants of Spanish FIS (01/3153; 02/1358 & 02/1041). |
| Databáze: | OpenAIRE |
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