Recombinant 1F9 spidroin microgels for murine full-thickness wound repairing
| Autor: | V. G. Bogush, A. Yu. Arkhipova, M. S. Kotlyarova, Debabov Vladimir G, Mikhail P. Kirpichnikov, L. I. Davydova, Igor I. Agapov, Mikhail M. Moisenovich, A. V. Goncharenko, T. V. Vasil’eva, N. V. Malyuchenko |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biophysics Biochemistry law.invention Mice 03 medical and health sciences 0302 clinical medicine Dermis law medicine Animals Skin repair Wound Healing integumentary system Spidroin Chemistry Regeneration (biology) Hydrogels General Chemistry General Medicine Anatomy Recombinant Proteins Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Self-healing hydrogels Recombinant DNA Female Epidermis Fibroins Wound healing 030217 neurology & neurosurgery |
| Zdroj: | Doklady Biochemistry and Biophysics. 466:9-12 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | The study of the stimulating effect of the microgels (MGs) based on recombinant 1F9 spidroin on the regeneration of the deep skin wound in mice was carried out. The use of spidroin MGs was shown to increase significantly the quality of healing compared to the control. The introduction of the MG in the wound edges led to recovery of all the structural elements of the skin: the epidermis, the dermis, including vascular and nervous network, in the periphery of the wound underlying muscles, and skin appendages (sebaceous and sweat glands and hair follicles) was revealed. |
| Databáze: | OpenAIRE |
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