Nuclear nonmetastatic protein 23-H1 expression and epithelial-mesenchymal transition in laryngeal carcinoma: A pilot investigation
| Autor: | Alessandro Martini, Luciano Giacomelli, Stella Blandamura, Rosario Marchese-Ragona, Ambrogio Fassina, Rocco Cappellesso, Gino Marioni, Elena Fasanaro, Giancarlo Ottaviano, Vincenza Guzzardo, Niccolò Favaretto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Larynx Male Epithelial-Mesenchymal Transition Pilot Projects 03 medical and health sciences 0302 clinical medicine Antigens CD medicine Carcinoma Humans Epithelial–mesenchymal transition Laryngeal Neoplasms Aged Zinc Finger E-box Binding Homeobox 2 Zinc finger Transition (genetics) business.industry Zinc Finger E-box-Binding Homeobox 1 Middle Aged NM23 Nucleoside Diphosphate Kinases medicine.disease Cadherins Phenotype 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Homeobox Immunohistochemistry Female Snail Family Transcription Factors business |
| Zdroj: | Headneck. 40(9) |
| ISSN: | 1097-0347 |
| Popis: | BACKGROUND In epithelial-to-mesenchymal transition, epithelial cells lose their features, acquiring a mesenchymal-like phenotype. Nm23-H1 protein relates to tumor cells' metastatic potential, its low expression in carcinomas often meaning a poor prognosis. This study newly investigated the role of nuclear nm23-H1 in laryngeal squamous cell carcinoma epithelial-to-mesenchymal transition. METHODS Immunohistochemical analyses of nuclear nm23-H1, E-cadherin, N-cadherin, Snail, Zinc finger E-box binding homeobox (ZEB)1, and ZEB2 were performed in 33 consecutive patients with laryngeal SCC. RESULTS Mean nuclear nm23-H1 expression was lower in patients whose disease recurred (P = .0046). Disease-free survival (DFS) was longer for patients whose nuclear nm23-H1 expression was ≥10% (P = .0083). Nuclear nm23-H1 and E-cadherin expressions correlated directly (P = .018). Mean E-cadherin expression was lower in patients whose disease recurred (P = .03). The DFS was shorter in patients with ZEB2 expression ≥5% (P = .006). CONCLUSIONS Nuclear nm23-H1 expression warrants further investigation in laryngeal SCC as a prognostic marker identifying patients at higher risk of recurrence. nm23-H1 targeted treatments may be capable of regulating epithelial-to-mesenchymal transition. |
| Databáze: | OpenAIRE |
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