Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study
| Autor: | N. J. Howard, Paul Zev Zimmet, Ian R. Mackay, Charles F. Verge, Merrill J. Rowley, H. Hulinska, S. Kamath, A. Sharp, Ilja Hulinsky, T. Arundel, R. A. Silvestrini, Martin Silink, M. Egan |
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| Rok vydání: | 1994 |
| Předmět: |
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medicine.medical_specialty Radioimmunoprecipitation Assay Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Glutamate decarboxylase Population Radioimmunoassay Enzyme-Linked Immunosorbent Assay Iodide Peroxidase Coeliac disease Islets of Langerhans Thyroid peroxidase Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Child Autoantibodies geography geography.geographical_feature_category biology business.industry Glutamate Decarboxylase Autoantibody Infant Newborn Infant medicine.disease Islet Celiac Disease Endocrinology Diabetes Mellitus Type 1 Child Preschool Immunology biology.protein Female Antibody New South Wales business |
| Zdroj: | Diabetologia. 37(11) |
| ISSN: | 0012-186X |
| Popis: | Sera obtained at diagnosis from 273 children (0–14 years) with insulin-dependent diabetes mellitus (IDDM) were studied to compare different autoantibody levels. The subjects comprise 75% of all incident cases in New South Wales, Australia, for a 2-year period (ascertainment >99% complete). Antibodies against glutamate decarboxylase were measured by radioimmunoprecipitation, insulin autoantibodies (on 176 sera collected within 4 days of initiation of insulin therapy) by radioimmunoassay, thyroid peroxidase and antigliadin IgA antibodies by enzyme-linked immunoassay, and anti-endomysial IgA and islet cell antibodies by indirect immunofluorescence. Reference ranges for anti-glutamate decarboxylase and insulin autoantibodies were determined in a group of non-diabetic children. Of the sera 69% were positive for anti-glutamate decarboxylase, 65% for insulin autoantibodies, 71% for islet cell antibodies (⩾20 Juvenile Diabetes Foundation units), 10% for anti-thyroid peroxidase, 2.6% for antigliadin and 3.0% for anti-endomysial antibodies. Islet cell antibodies and insulin autoantibodies were both negative in 13.7% of the sera, while only 5.8% were negative for all three of islet cell antibodies, insulin autoantibodies and anti-glutamate decarboxylase. There was a higher frequency of anti-glutamate decarboxylase among girls than boys (75% vs 63%, p=0.03) and a negative correlation between the level of insulin autoantibodies and age at diagnosis (r=−0.41, p |
| Databáze: | OpenAIRE |
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