Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

Autor:	Christophe Guervilly, Antoine Roch, Benjamin Coiffard, Mélanie Adda, Florence Daviet, Nicolas Persico, Kathia Chaumoitre, Jean-Marie Forel, Sami Hraiech, Annabelle Hamon, Jeremy Bourenne, Ugo Scemama, Laurent Papazian
Přispěvatelé:	Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	CT scan medicine.medical_specialty ARDS Critical Care and Intensive Care Medicine [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Fibroproliferation 03 medical and health sciences 0302 clinical medicine Fibrosis Anesthesiology [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Medicine ComputingMilieux_MISCELLANEOUS Lung Acute respiratory distress syndrome business.industry Surrogate endpoint Research lcsh:Medical emergencies. Critical care. Intensive care. First aid 030208 emergency & critical care medicine Retrospective cohort study lcsh:RC86-88.9 medicine.disease Procollagen peptidase medicine.anatomical_structure 030228 respiratory system Biomarker (medicine) Lung fibrosis Radiology business Scoring Procollagen
Zdroj:	Annals of Intensive Care, Vol 9, Iss 1, Pp 1-8 (2019) Annals of Intensive Care Annals of Intensive Care, 2019, 9 (1), pp.42. ⟨10.1186/s13613-019-0516-9⟩
ISSN:	2110-5820
Popis:	Background Lung fibroproliferation in ARDS patients is associated with mortality. Alveolar procollagen III (NT-PCP-III) is a validated biomarker of lung fibroproliferation. A chest CT scan could be useful for the diagnosis of lung fibroproliferation. The aim of this study was to identify lung fibroproliferative CT scan aspects in ARDS patients with high levels of NT-PCP-III. Results This retrospective study included ARDS patients who had at least one assessment of alveolar NT-PCP-III and a chest CT scan within 3 days before or after NT-PCP-III determination. An alveolar level of NT-PCP-III > 9 µG/L indicated fibroproliferation. The CT scan was scored on interstitial and alveolar abnormalities. Each lobe was scored from 0 to 5 according to the severity of the abnormalities. The crude score and the corrected score (related to the number of scored lobes in cases of important lobar condensation or lobectomy) were used. One hundred ninety-two patients were included, for a total of 228 alveolar NT-PCP-III level and CT scan ‘couples’. Crude and corrected CT scan fibrosis scores were higher in the fibroproliferation group compared with the no fibroproliferation group (crude score: 12 [9–17] vs 14 [11–12], p = 0.002; corrected score: 2.8 [2.2–4.0] vs 3.4 [2.5–4.7], p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d5b6264e85268522bd1a09b8f94f6f http://link.springer.com/article/10.1186/s13613-019-0516-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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