Successful Crizotinib Rechallenge After Crizotinib-induced Interstitial Lung Disease
| Autor: | Daisuke Tamura, Motoko Tachihara, Hiroshi Otera, Yasuhiro Funada, Yoshihiro Nishimura, Yumiko Ishikawa, Kazuyuki Kobayashi, Suya Hori |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Antineoplastic Agents Hormonal Pyridines Prednisolone Crizotinib Carcinoma Non-Small-Cell Lung Internal medicine Bronchoscopy medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes Lung cancer Protein Kinase Inhibitors Aged Lung medicine.diagnostic_test business.industry Interstitial lung disease General Medicine respiratory system medicine.disease Lymphoma Treatment Outcome Bronchoalveolar lavage medicine.anatomical_structure Pyrazoles Adenocarcinoma Drug Therapy Combination Lung Diseases Interstitial Tomography X-Ray Computed business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Japanese Journal of Clinical Oncology. 44:762-764 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | We report the case of a 70-year-old Japanese male diagnosed with advanced lung adenocarcinoma harboring the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene. As soon as crizotinib was administered, tumor shrank immediately. On Day 25, he developed interstitial lung disease. Bronchoalveolar lavage fluid analysis demonstrated elevated lymphocytes fractionation. A drug lymphocyte stimulating test for crizotinib with the bronchoalveolar lavage lymphocytes was negative. Crizotinib administration was discontinued, but a life-threatening flare of tumor growth occurred. Since there was no alternative treatment for the lung cancer, we restarted crizotinib in combination with prednisolone. The patient experienced neither disease progression nor recurrence of interstitial lung disease at 6 months. In cases in which no alternate treatment is known, crizotinib retreatment combined with steroid therapy after crizotinib-induced interstitial lung disease could be considered after a careful consideration of the potential risks and benefits. |
| Databáze: | OpenAIRE |
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