Dipasperoside B, a New Trisiridoid Glucoside from Dipsacus asper
| Autor: | Feng Li, Ken Tanaka, Yasuhiro Tezuka, Shiro Watanabe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Iridoid
medicine.drug_class Stereochemistry Cell Survival Iridoid Glucosides Trimer Plant Science Nitric Oxide 01 natural sciences Nitric oxide chemistry.chemical_compound Mice Glucoside Glucosides Oxaloacetic acid Drug Discovery medicine Moiety Animals Cytotoxicity Pharmacology Molecular Structure 010405 organic chemistry Chemistry General Medicine Dipsacaceae 0104 chemical sciences 010404 medicinal & biomolecular chemistry RAW 264.7 Cells Complementary and alternative medicine Cell culture |
| Zdroj: | Natural product communications. 11(7) |
| ISSN: | 1934-578X |
| Popis: | Dipasperoside B (1), isolated from the root of Dipsacus asper, was determined to be a first example of naturally occurring iridoid glucoside trimer with an unusual skeleton featuring oxaloacetic acid derived moiety coupled with a secoiridoid nucleus in the central part, on the basis of spectroscopic data. Dipasperoside B (1) revealed the inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cell line, with an IC50 value of 21.3 μM, identical to a positive control, NG-monomethyl-L-arginine (L-NMMA, IC50 22.6 μM), without any significant cytotoxicity. |
| Databáze: | OpenAIRE |
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