Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity

Autor: John R. Miller, Giorge Filousis, Cryshanthi Papadopoulou, Catherine Dodorou, Mavroudis A. Demertzis, Dimitra Kovala-Demertzi
Rok vydání: 2001
Předmět:
Antifungal Agents
Magnetic Resonance Spectroscopy
compound
Organoplatinum Compounds
3-hexamethyleneiminylthiosemicarbazones
Crystal structure
ligand
Crystallography
X-Ray
Biochemistry
p-isopropylbenzaldehyde thiosemicarbazone
Supramolecular assembly
Antineoplastic Agents/*chemical synthesis/chemistry/*pharmacology
chemistry.chemical_compound
Anti-Infective Agents
Candida albicans
platinum(ii) complex
Escherichia coli/drug effects
Molecular Structure
Hydrogen bond
Nuclear magnetic resonance spectroscopy
Anti-Bacterial Agents
palladium(ii) complexes
Spectrophotometry
copper(ii)
Palladium
Thiosemicarbazones
crystal structure
Staphylococcus aureus
Organoplatinum Compounds/*chemical synthesis/chemistry/*pharmacology
Stereochemistry
Staphylococcus aureus/drug effects
chemistry.chemical_element
Antineoplastic Agents
in-vitro
Anti-Infective Agents/*chemical synthesis/chemistry/*pharmacology
Inorganic Chemistry
DNA-binding
biological-activity
Pyridine
Escherichia coli
spectroscopic study
Semicarbazone
cytotoxic activity
thiosemicarbazonato complex
Thiosemicarbazones/*chemical synthesis/chemistry/*pharmacology
Candida albicans/drug effects
chemistry
antibacterial
antifungal
antineoplastic activity
Platinum
Antifungal Agents/chemical synthesis/chemistry/pharmacology
Zdroj: Journal of Inorganic Biochemistry. 86:555-563
ISSN: 0162-0134
DOI: 10.1016/s0162-0134(01)00224-0
Popis: An interesting series of new platinum complexes has been synthesized by the reaction of Na(2)ptCl(4) with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)CI], [Pt(HAcTsc),]Cl-2 and [Pt(AcTsc)(2)], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)CI] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH-CI), pi-pi and weak Pt-Pt and Pt-pi contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(fl) complexes, [Pd(AcTsc)CI], [d(HAcTsc),]Cl, and [Pd(AcTsc),], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram- bacteria. Additionally, the complexes [Pt(AcTsc),] and [Pd(AcTsc),] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] while the rest, display marginal cytogenetic and antitumour effects. (C) 2001 Elsevier Science BY All rights reserved. J Inorg Biochem
Databáze: OpenAIRE
Externí odkaz: