Carvedilol Therapy Is Associated with an Improvement in Left Atrial Appendage Function in Patients with Congestive Heart Failure
| Autor: | Şakir Arslan, Serdar Sevimli, Yekta Gürlertop, Hüseyin Şenocak, Mahmut Acikel, Mustafa Yilmaz, M. Kemal Erol, Engin Bozkurt, Fuat Gundogdu |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Adrenergic beta-Antagonists Carbazoles Blood Pressure Propanolamines Heart Rate Left atrial Internal medicine Heart rate medicine Humans Atrial Appendage Radiology Nuclear Medicine and imaging In patient Carvedilol Heart Failure Observer Variation Appendage Ejection fraction business.industry Middle Aged medicine.disease Echocardiography Doppler Treatment Outcome Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Echocardiography Transesophageal medicine.drug |
| Zdroj: | Echocardiography. 24:623-628 |
| ISSN: | 1540-8175 0742-2822 |
| Popis: | Heart failure is one of the leading death reasons in the world. Left atrial appendage (LAA) is of great importance in maintaining cardiac function. We examined the effect of carvedilol therapy on left atrial appendage functions in patients with symptomatic congestive heart failure. Twenty patients with symptomatic congestive heart failure and resting ejection fraction < or = 40% were included in this study. LAA was visualized by transesophageal echocardiography. LAA area change (LAAAC), LAA empty velocity (LAAEV) and LAA empty velocity time integral (LAAEVTI) were calculated as the average of five cardiac cycles. A minimum dose of carvedilol administered to each patient, was titrated up to maximal dose that the patients could tolerate, during an 8-week period. After the third month of completing treatment, a second transthoracic and transesophageal echocardiographic study was performed. Heart rate (P < 0.001), systolic (P = 0.002) blood pressures were reduced by carvedilol therapy at the end of the third month. LAAEV (P < 0.001), LAAEVTI (P < 0.001), and LAAAC (P < 0.001) were significantly increased at the end of the third month of carvedilol therapy. This study indicates that in patients with symptomatic congestive heart failure, carvedilol therapy is associated with an improvement in left atrial appendage function. |
| Databáze: | OpenAIRE |
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