FUNDUS AUTOFLUORESCENCE IN RUBELLA RETINOPATHY: Correlation With Photoreceptor Structure and Function
| Autor: | Fred K. Chen, Avenell L. Chew, Enid Chelva, Ivy Tang, Danuta Bukowska, Sue Ling Wan, David A. Mackey |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Pathology medicine.medical_specialty genetic structures Fundus Oculi Retinal Cone Photoreceptor Cells Rubella 03 medical and health sciences 0302 clinical medicine Retinal Diseases Retinitis pigmentosa medicine Humans Fluorescein Angiography Child Congenital rubella syndrome medicine.diagnostic_test business.industry General Medicine Middle Aged Fluorescein angiography medicine.disease eye diseases Scanning laser ophthalmoscopy Ophthalmology Autofluorescence 030221 ophthalmology & optometry Visual Field Tests sense organs Visual Fields business Microperimetry 030217 neurology & neurosurgery Tomography Optical Coherence |
| Zdroj: | Retina (Philadelphia, Pa.). 37(1) |
| ISSN: | 1539-2864 |
| Popis: | To illustrate altered fundus autofluorescence in rubella retinopathy and to investigate their relationships with photoreceptor structure and function using multimodal imaging.The authors report four cases of rubella retinopathy aged 8, 33, 42, and 50 years. All patients had dilated clinical fundus examination; wide-field color photography; blue, green, and near-infrared autofluorescence imaging and spectral domain optical coherence tomography. Two patients also underwent microperimetry and adaptive optics imaging. En face optical coherence tomography, cone mosaic, and microperimetry were coregistered with autofluorescence images. The authors explored the structure-function correlation.All four patients had a "salt-and-pepper" appearance on dilated fundus examination and wide-field color photography. There were variable-sized patches of hypoautofluorescence on both blue and near-infrared excitation in all four patients. Wave-guiding cones were visible and retinal sensitivity was intact over these regions. There was no correlation between hypoautofluorescence and regions of attenuated ellipsoid and interdigitation zones. Hyperautofluorescent lesions were also noted and some of these were pseudo-vitelliform lesions.Patchy hypoautofluorescence on near-infrared excitation can be a feature of rubella retinopathy. This may be due to abnormal melanin production or loss of melanin within retinal pigment epithelium cells harboring persistent rubella virus infection. Preservation of the ellipsoid zone, wave-guiding cones, and retinal sensitivity within hypoautofluorescent lesions suggest that these retinal pigment epithelium changes have only mild impact on photoreceptor cell function. |
| Databáze: | OpenAIRE |
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