Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests
| Autor: | Joyce Mendes-Gomes, Bruno Lobão-Soares, Tatiana Tocchini Felippotti, Jade P. Cysne-Coimbra, Norberto Cysne Coimbra, D.H. Elias-Filho, Tatiana Paschoalin-Maurin, Audrey Francisco Biagioni, Alexandre Kanashiro, Rafael Carvalho Almada, Gabriel Shimizu Bassi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.drug_class
lcsh:RC435-571 Maze learning Panic attacks Review Article Innate fear Anxiolytic Developmental psychology 03 medical and health sciences 0302 clinical medicine Predatory behavior lcsh:Psychiatry medicine elevated T-maze test Elevated plus-maze test Animals Rats Wistar Maze Learning Instinct Prey versus snakes paradigms Behavior Animal prey versus snakes paradigms elevated plus-maze test Panic Snakes Fear T-maze Anxiety Disorders polygonal arenas for snakes 030227 psychiatry COMPORTAMENTO ANIMAL Rats Polygonal arenas for snakes Psychiatry and Mental health Behavioral test Elevated T-maze test Predatory Behavior Anticipatory anxiety Anxiety Panic Disorder panic attacks medicine.symptom Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN Brazilian Journal of Psychiatry v.39 n.1 2017 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Brazilian Journal of Psychiatry Revista Brasileira de Psiquiatria, Volume: 39, Issue: 1, Pages: 72-83, Published: 06 FEB 2017 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Psychiatry, Iss 0 |
| Popis: | Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs. |
| Databáze: | OpenAIRE |
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