Effect of MRI-based semiautomatic size-assessment in cerebral metastases on the RANO-BM classification
| Autor: | H. C. Bauknecht, Eberhard Siebert, Claudia Wolf, Patrick A. Hein, Randolf Klingebiel, L. Bornemann, Georg Bohner |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Contrast Media 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Medicine Humans Radiology Nuclear Medicine and imaging Neuroradiology Aged Retrospective Studies Observer Variation medicine.diagnostic_test Average diameter business.industry Brain Neoplasms Disease progression Brain Reproducibility of Results Magnetic resonance imaging Middle Aged Image Enhancement Magnetic Resonance Imaging Tumor Burden Response assessment Female Neurology (clinical) Neurosurgery business Nuclear medicine 030217 neurology & neurosurgery |
| Popis: | Aim Evaluation of a semiautomatic software algorithm for magnetic resonance imaging (MRI)-based assessment of cerebral metastases in cancer patients. Material and Methods Brain metastases (n = 131) in 38 patients, assessed by contrast-enhanced MRI, were retrospectively evaluated at two timepoints (baseline, follow-up) by two experienced neuroradiologists in a blinded manner. The response assessment in neuro-oncology (RANO) criteria for brain metastases (RANO-BM) were applied by means of a software (autoRANO-BM) as well as manually (manRANO-BM) at an interval of 3 weeks. Results The average diameter of metastases was 12.03 mm (SD ± 6.66 mm) for manRANO-BM and 13.97 mm (SD ± 7.76 mm) for autoRANO-BM. Diameter figures were higher when using semiautomatic measurements (median = 11.8 mm) as compared to the manual ones (median = 10.2 mm; p = 0.000). Correlation coefficients for intra-observer variability were 0.993 (autoRANO-BM) and 0.979 (manRANO-BM). The interobserver variability (R1/R2) was 0.936/0.965 for manRANO-BM and 0.989/0.998 for autoRANO-BM. A total of 19 lesions (15%) were classified differently when using semiautomatic measurements. In 14 cases with suspected disease progression by manRANO-BM a stable course was found according to autoRANO-BM. Conclusion Computerized measuring techniques can aid in the assessment of cerebral metastases by reducing examiner-dependent effects and may consequently result in a different classification according to RANO-BM criteria. |
| Databáze: | OpenAIRE |
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