Use of the suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists
| Autor: | Lawrence W. Fitzgerald, Anthony J. Cocuzza, Steven Culp, Dennis R. Chidester, Paul J. Gilligan |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Chemistry Aryl Organic Chemistry Clinical Biochemistry Nitro compound Pharmaceutical Science Biological activity Receptors Corticotropin-Releasing Hormone Biochemistry Combinatorial chemistry Chemical synthesis Structure-Activity Relationship Corticotropin-releasing hormone chemistry.chemical_compound CRH Receptor nervous system Suzuki reaction Heterocyclic Compounds Drug Discovery Molecular Medicine Receptor Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:1063-1066 |
| ISSN: | 0960-894X |
| Popis: | The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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