CYP1A1 and CYP2D6 Gene Polymorphisms in Israeli Jewish Women With Cervical Cancer
| Autor: | Amiram Bar-Am, Tova Morad, Ben Peleg, Tamar Safra, Chavah Peretz, Guy Gutman, Dan Grisaru |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Genotype Population Uterine Cervical Neoplasms Polymerase Chain Reaction digestive system Internal medicine Genetic variation Cytochrome P-450 CYP1A1 medicine Humans Israel Allele Risk factor skin and connective tissue diseases education Cervix Allele frequency Gynecology Cervical cancer education.field_of_study Polymorphism Genetic business.industry Obstetrics and Gynecology respiratory system Prognosis medicine.disease medicine.anatomical_structure Cytochrome P-450 CYP2D6 Case-Control Studies Jews Female business |
| Zdroj: | International Journal of Gynecological Cancer. 19:1300-1302 |
| ISSN: | 1048-891X |
| DOI: | 10.1111/igc.0b013e3181b9fa5d |
| Popis: | Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method. Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003). Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population. |
| Databáze: | OpenAIRE |
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