Expression of a Tumor Stem Cell Marker (Aldehyde Dehydrogenase 1-ALDH1) in Benign Epithelial Odontogenic Lesions

Autor: Gustavo Alcântara da Trindade, Leorik Pereira da Silva, Pedro Paulo de Andrade Santos, Leão Pereira Pinto, Lélia Batista de Souza
Rok vydání: 2022
Předmět:
Zdroj: Head Neck Pathol
ISSN: 1936-0568
DOI: 10.1007/s12105-022-01430-z
Popis: The morphological diversity and different biological behaviors of human lesions has been attributed to the presence of cells with stem cell (SC) characteristics. Among SC markers, ALDH1 has been used in studies investigating different neoplasms and high expression of this marker was associated with clinicopathological features and prognosis in some groups. The aim of this study was to analyze the presence and distribution of SCs based on the expression of ALDH1 in epithelial odontogenic cysts and tumors. The sample consisted of 80 cases (20 dentigerous cysts (DCs), 20 odontogenic keratocysts (OKCs), 20 ameloblastomas (AMs), and 20 adenomatoid odontogenic tumors (AOTs). An immunoreactivity score was obtained from the percentage of positive cells and intensity of immunostaining. A level of 5% (p
Databáze: OpenAIRE
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