Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery
| Autor: | Samuel I. Stupp, Miranda So, Neel A. Mansukhani, Melina R. Kibbe, Charles M. Rubert Pérez, Erica B. Peters, Zheng Wang, Mazen Albaghdadi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chemistry Biomedical Engineering Peptide 02 engineering and technology 021001 nanoscience & nanotechnology Article General Biochemistry Genetics and Molecular Biology Biomaterials 03 medical and health sciences 030104 developmental biology Targeted drug delivery Nanofiber LDL receptor Drug delivery Peptide amphiphile Biophysics 0210 nano-technology Liver X receptor Peptide sequence |
| Zdroj: | Advanced Biosystems. 2:1700123 |
| ISSN: | 2366-7478 |
| Popis: | Co-assembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in LDL receptor knockout mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, non-targeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis. |
| Databáze: | OpenAIRE |
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