B-cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen
| Autor: | C. I. E. Smith, L. Borgonovo, E. ösby, R. Lenkei, Anna Porwit, Leif Hammarström |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.drug_class
Fluorescent Antibody Technique Monoclonal antibody Antigen Antigens Neoplasm medicine Humans Cytotoxic T cell Lymphocyte function-associated antigen 1 Receptor Aged B-Lymphocytes biology Chemistry T-cell receptor Hematology General Medicine Flow Cytometry Molecular biology Lymphocyte Function-Associated Antigen-1 Leukemia Lymphoid Antigens Surface biology.protein Autoradiography Female Antibody CD8 |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1987.tb00775.x |
| Popis: | The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia. The cells also had an unusual type of rod-like cytoplasmic immunoglobulin of IgM/lambda type as seen by light, fluorescence and electron microscopy, and displayed several antigens characteristic for B lymphocytes. Gene rearrangement analysis showed rearrangement of mu heavy chain gene. In spite of an expression of CD8 antigen, T-cell receptor genes were not rearranged. |
| Databáze: | OpenAIRE |
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