Antifungal Activity of the Sesquiterpene Lactones from Psephellus bellus
| Autor: | Beata Kamińska-Kolat, Gerard Nowak, Honorata Kubisiak-Rzepczyk, Zygmunt Adamski, Justyna Gornowicz-Porowska, Joanna Nawrot, Anna Kroma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
Plant Science Rhodotorula Sesquiterpene Article Psephellus bellus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food sesquiterpene lactones Trichophyton MTT assay Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Ecology biology Traditional medicine antifungal activity Botany biology.organism_classification chemistry Phytochemical QK1-989 030220 oncology & carcinogenesis Herb Scopulariopsis Microsporum |
| Zdroj: | Plants Volume 10 Issue 6 Plants, Vol 10, Iss 1180, p 1180 (2021) |
| ISSN: | 2223-7747 |
| Popis: | Due to increasing resistance of pathogenic fungi to antifungal treatments, new types of drugs are needed. For this purpose, active substances with antifungal properties occurring in natural compounds should be considered. The herb Psephellus bellus shows strong antifungal activity and is characterized by unique guaianolides, which have an ester on C-2. Thus, a specialized method of isolation and testing was applied to assess the pharmacological effects of these guaianolides. After phytochemical analysis (chromatography and spectral methods), selected lipophilic compounds and the herb extract of this species containing 26 sesquiterpene lactones were tested. The antifungal effect of the herbal compounds was determined on clinical strains of fungi Candida, Rhodotorula, Trichophyton, Microsporum, and Scopulariopsis using a diffusion test. The MTT assay was employed to study the cytotoxic effects of the extract against human fibroblasts. Statistical analysis was performed. All analyzed compounds exhibited antifungal activity in cultivations suitable for assessment. Most lipophilic cebellins from Psephellus bellus prevent the growth of most fungal strains. |
| Databáze: | OpenAIRE |
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