Influence of autogenous platelet concentrate on combined GTR/graft therapy in intrabony defects: a 7-year follow-up of a randomized prospective clinical split-mouth study
| Autor: | Fabian Cieplik, M. Christgau, Gottfried Schmalz, Laura Tabenski, Wolfgang Buchalla, Karl-Anton Hiller |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Blood transfusion medicine.medical_treatment Bleeding on probing Alveolar Bone Loss Dentistry Platelet Transfusion law.invention Blood Transfusion Autologous Tooth Loss Randomized controlled trial law Periodontal Attachment Loss Medicine Humans Periodontal Pocket Gingival Recession Platelet concentrate Longitudinal Studies Prospective Studies Prospective cohort study Survival analysis Bone Transplantation business.industry Dental Plaque Index Gingivitis Surgery Platelet transfusion Treatment Outcome Platelet-rich plasma Tooth Extraction Guided Tissue Regeneration Periodontal Periodontics Patient Compliance medicine.symptom Periodontal Index business Follow-Up Studies |
| Zdroj: | Journal of clinical periodontology. 39(5) |
| ISSN: | 1600-051X |
| Popis: | Objectives To investigate the influence of autogenous platelet concentrate (APC) on the long-term regeneration outcome 7 years after guided tissue regeneration (GTR) in deep intrabony periodontal defects. Material and methods In 25 patients, two deep contra-lateral intrabony defects were treated according to GTR (randomized split-mouth-design). In the test defects, APC was additionally applied. After 7 years, healing results were assessed clinically by a blinded examiner and compared to baseline and 12-months results. Furthermore, a tooth survival analysis was performed. Results After 7 years, 23 patients were available for survival analysis and 16 patients for split-mouth analysis; 84% of the test and control teeth were still in situ. In both groups, the median attachment level of 10.5 mm [(25/75%): test 9.0/13.0, control 10.0/12.0] at baseline was significantly (p ≤ 0.05) reduced to 6.0 mm [test 4.0/6.8, control 5.0/7.0] after 1 year. Six years later, it had increased again to 7.0 mm in test sites [5.3/10.0] (p ≤ 0.05) and had remained stable in control sites [5.0/7.8] (p > 0.05). Bleeding on Probing (BOP) had increased in both groups. During the last 6 years, only 26% of the patients received a structured supportive periodontal therapy in the clinic. Conclusion Within its limitations, the present study indicates that the clinical outcome of GTR therapy can be maintained over 7 years. However, the additional use of APC may even have a possibly negative influence on the long-term stability. |
| Databáze: | OpenAIRE |
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