Lactic Acidosis in Prostate Cancer:Consider the Warburg Effect
| Autor: | Carl E H Siegert, Johannes C. van der Mijn, Carel J M van Noesel, Aernout C Ogilvie, Annabeth E Wassenaar, Mathijs J Kuiper |
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| Přispěvatelé: | Medical oncology, CCA - Cancer Treatment and quality of life |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Nonsense mutation Respiratory compensation Tachypnea Gastroenterology lcsh:RC254-282 03 medical and health sciences Prostate cancer Internal medicine IDH1 mutations Case report medicine PTEN mutations Acidosis business.industry Lactic acidosis Metabolic reprogramming medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Warburg effect Pulmonary embolism 030104 developmental biology Oncology Mutation PIK3CA mutations medicine.symptom business p53 mutations |
| Zdroj: | van der Mijn, J C, Kuiper, M J, Siegert, C E H, Wassenaar, A E, van Noesel, C J M & Ogilvie, A C 2017, ' Lactic Acidosis in Prostate Cancer : Consider the Warburg Effect ', Case Reports in Oncology, vol. 10, no. 3, pp. 1085-1091 . https://doi.org/10.1159/000485242 Case Reports in Oncology Case Reports in Oncology, 10(3), 1085-1091. S. Karger AG Case Reports in Oncology, Vol 10, Iss 3, Pp 1085-1091 (2017) |
| ISSN: | 1662-6575 |
| DOI: | 10.1159/000485242 |
| Popis: | Lactic acidosis is a commonly observed clinical condition that is associated with a poor prognosis, especially in malignancies. We describe a case of an 81-year-old patient who presented with symptoms of tachypnea and general discomfort. Arterial blood gas analysis showed a high anion gap acidosis with a lactate level of 9.5 mmol/L with respiratory compensation. CT scanning showed no signs of pulmonary embolism or other causes of impaired tissue oxygenation. Despite treatment with sodium bicarbonate, the patient developed an adrenalin-resistant cardiac arrest, most likely caused by the acidosis. Autopsy revealed Gleason score 5 + 5 metastatic prostate cancer as the most probable cause of the lactic acidosis. Next-generation sequencing indicated a nonsense mutation in the TP53 gene (887delA) and an activating mutation in the PIK3CA gene (1634A>G) as candidate molecular drivers. This case demonstrates the prevalence and clinical relevance of metabolic reprogramming, frequently referred to as “the Warburg effect,” in patients with prostate cancer. |
| Databáze: | OpenAIRE |
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