Evaluation of anti-fertility activity of Tabernaemontana divaricata (Linn) R.Br. leaves in rats
Autor: | Sachin Jain, Lokesh Deb, Avijeet Jain, K. R. Dutt, Deepak Kumar Jain |
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Rok vydání: | 2010 |
Předmět: |
medicine.medical_specialty
Ethinyl oestradiol Tabernaemontana Tabernaemontana divaricata Uterus Dermatan Sulfate Plant Science Biochemistry Analytical Chemistry chemistry.chemical_compound Contraceptive Agents Internal medicine medicine Animals Rats Wistar Medicinal plants Ethanol biology Traditional medicine Plant Extracts Organic Chemistry Chondroitin Sulfates Estrogens biology.organism_classification Epithelium Rats Plant Leaves medicine.anatomical_structure Endocrinology chemistry Female Heparitin Sulfate Once daily Anti fertility |
Zdroj: | Natural product research. 24(9) |
ISSN: | 1478-6427 |
Popis: | The aim of the present study was to assess the anti-fertility activity of ethanolic extracts of Tabernaemontana divaricata (TD) leaves in oestrogenic activity models in immature female rats. Mature green leaves of TD were collected and authenticated. Extractions of the dried leaves were carried out with ethanol in a Soxhlet's apparatus. For oestrogenic activity, the extracts were administered orally once daily at a dose of 200 and 400 mg kg(-1), and the activity was compared with the standard drug ethinyl oestradiol (0.02 mg). The extracts caused significant increase in uterine weight compared to the control. The ethanolic extract exhibited oestrogenic activity. The histological study of epithelium tissues with the 400 mg of TD extract-treated animals showed increases in the height of the luminal epithelium and loose edematous stroma when compared with the 200 mg of TD extract-treated group of animals. However, this was better than the control group of animals. Enhanced uterine weight and increase in the height of luminal epithelium and histological characteristics suggest that TD extract may be useful in anti-fertility therapy. |
Databáze: | OpenAIRE |
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