Antileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives
| Autor: | N. G. Urlyapova, Vadim Makarov, A. D. Daudova, A. A. Yuschenko |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Microbial Viability Dose-Response Relationship Drug biology Chemistry Stereochemistry Treatment outcome Drug Evaluation Preclinical Leprostatic Agents General Medicine Pharmacology biology.organism_classification General Biochemistry Genetics and Molecular Biology Mycobacterium leprae Mice Treatment Outcome Thiocarbamates Leprosy Mice Inbred CBA Animals |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 145:446-448 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-008-0114-6 |
| Popis: | Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment. |
| Databáze: | OpenAIRE |
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