Congenital Growth Hormone (GH) Deficiency and Atherosclerosis: Effects of GH Replacement in GH-Naive Adults
| Autor: | Viviane C. Campos, Giovanni Parmigiani, Celi Marques-Santos, Rossana M. C. Pereira, Érica O. Alves, Catarine T. Farias, Manuel H. Aguiar-Oliveira, Carla R. P. Oliveira, Fernando D Anjos-Andrade, Roberto Ximenes, Francielle T. Oliveira, José Augusto Barreto-Filho, Amanda L. Blackford, Roberto Salvatori, Argemiro D’Oliveira, Joselina Luzia Menezes Oliveira, Adão C. Nascimento-Junior |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Clinical Biochemistry Blood Pressure Growth hormone Biochemistry Endocrinology Heart Rate Risk Factors Internal medicine Ghrh receptor Humans Medicine Insulin-Like Growth Factor I Exercise Anthropometry biology Human Growth Hormone business.industry Vascular disease Cholesterol HDL Biochemistry (medical) C-reactive protein Cholesterol LDL Middle Aged Atherosclerosis medicine.disease Obesity Carotid Arteries Blood pressure Echocardiography Delayed-Action Preparations Growth Hormone biology.protein Female Insulin Resistance Gh replacement business GH Deficiency |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:4664-4670 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2007-1636 |
| Popis: | GH deficiency (GHD) in adults is associated with increased abdominal adiposity and systolic blood pressure, total and low-density lipoprotein cholesterol, and C-reactive protein.We have studied the effects of 6-month GH replacement therapy in 20 adult members of a large Brazilian kindred with lifelong severe and isolated GHD due to a homozygous mutation in GHRH receptor gene (46 +/- 14.5 yr; 122 +/- 7.7 cm; 36.7 +/- 5.4 kg; 10 men). Subjects were studied at baseline, after 6-month bimonthly depot GH injections (Nutropin Depot; Genentech, Inc., South San Francisco, CA) [post GH (pGH)], and after 6- and 12-month washout.Despite modest trough serum IGF-I increase, GH replacement therapy caused a decrease in skinfolds and in waist-hip ratio, with a rebound increase at 12 months. Total and low-density lipoprotein cholesterol were reduced pGH and returned to baseline at 6 months. High-density lipoprotein cholesterol increased pGH, but at 12 months was lower than baseline. A progressive increase in left ventricular mass index, posterior wall, and septum thickness occurred from pGH to 12 months, and of carotid intima-media thickness, from 6 to 12 months. Individuals were 6, 16, and 52 times more likely to have an atherosclerotic carotid plaque at pGH, 6 and 12 months, respectively, when compared with baseline.In patients with lifetime isolated GHD, 6-month treatment with GH has reversible beneficial effects on body composition and metabolic profile, but it causes a progressive increase in intima-media thickness and in the number of atherosclerotic carotid plaques. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|