Helicobacter pyloriinfection in children with celiac disease
Autor: | Cigdem Arikan, Masallah Baran, Sema Aydogdu, Rasit Vural Yagci, Gokhan Tumgor, Murat Cakir, Hasan Ali Yuksekkaya |
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Rok vydání: | 2008 |
Předmět: |
Male
medicine.medical_specialty Adolescent Turkey Spirillaceae Comorbidity Severity of Illness Index Gastroenterology Coeliac disease Helicobacter Infections Age Distribution Reference Values Immunopathology Metaplasia Internal medicine Gastroscopy medicine Humans Sex Distribution Child Probability Helicobacter pylori biology business.industry Incidence Stomach Biopsy Needle Case-control study Prognosis bacterial infections and mycoses biology.organism_classification medicine.disease Immunohistochemistry Celiac Disease medicine.anatomical_structure Gastric Mucosa Case-Control Studies Child Preschool Female Gastritis medicine.symptom business |
Zdroj: | Scandinavian Journal of Gastroenterology. 43:1088-1093 |
ISSN: | 1502-7708 0036-5521 |
DOI: | 10.1080/00365520802101846 |
Popis: | To analyze the prevalence of Helicobacter pylori (H. pylori) infection in children with celiac disease (CD) and to examine the role of H. pylori infection in clinical, laboratory and histopathological presentations of CD.Data on 96 children with CD and 235 children who underwent endoscopy were compared for the prevalence and gastric histology pattern of H. pylori. Clinical presentation, laboratory and histological findings of CD children with and without H. pylori infection were compared.Twenty-one subjects (21.8%) in the CD group and 56 subjects (23.8%) in the control group had H. pylori gastritis. Gastric metaplasia is higher in CD patients with H. pylori gastritis (19%) than in patients without H. pylori gastritis (1.3%) and in the control group (3.5%) (p0.05 for all groups). Abdominal distension is more common at initial admission in CD patients with H. pylori gastritis (57.1% versus 14.6%, p0.05). No significant difference was found between H. pylori (+) and (-) CD patients in terms of prevalence of anemia, iron deficiency and iron-deficiency anemia. Only mild duodenal histological findings were more common in H. pylori patients (57.1% versus 26.7%, p0.05).CD may be associated with H. pylori gastritis, but it does not affect the clinical presentation of the disease, except for abdominal distension; CD is associated with mild duodenal lesions. A gluten-free diet improves the symptoms in all patients independently of the presence of H. pylori gastritis. Gastric metaplasia increases in the presence of H. pylori gastritis. Further prospective studies are needed to examine the clinical and histopathological outcomes of gastric metaplasia associated with H. pylori gastritis in CD patients. |
Databáze: | OpenAIRE |
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