Increased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsy

Autor:	M. Briones-Velasco, C. S. Cruz-Fuentes, Daniel San-Juan, A. Nani, Farah D. Lubin, R. M. Buentello-García, A. Pérez-Molina, Rosario Pérez-Molina, Mario Alonso-Vanegas, G. A. Martínez-Levy, Luisa Rocha, J. Cienfuegos, Félix Recillas-Targa
Rok vydání:	2016
Předmět:	Adult Male 0301 basic medicine Topiramate medicine.medical_specialty Fructose Biology Bioinformatics Hippocampus Temporal lobe Young Adult 03 medical and health sciences Epilepsy 0302 clinical medicine Neurotrophic factors Sertraline Internal medicine medicine Humans Hippocampus (mythology) RNA Messenger Promoter Regions Genetic Aged Brain-derived neurotrophic factor Hippocampal sclerosis Brain-Derived Neurotrophic Factor General Neuroscience Exons Methylation DNA Methylation Middle Aged medicine.disease 030104 developmental biology Endocrinology Epilepsy Temporal Lobe nervous system Anticonvulsants Female 030217 neurology & neurosurgery medicine.drug
Zdroj:	Neuroscience. 314:12-21
ISSN:	0306-4522
Popis:	A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampi of patients with pharmaco-resistant temporal lobe epilepsy (TLE) (n=24). Hippocampal sclerosis (HS) and pre-surgical pharmacological treatment were considered as clinical independent variables. A statistical significant increase for the BDNFVI (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b648b6703a7c8b73e0053fc02bad47 https://doi.org/10.1016/j.neuroscience.2015.11.046 Zobrazit plný text záznamu Full Text from ScienceDirect