Effects of fosinopril treatment on blood pressure during physical and mental stress test in essential hypertension
| Autor: | Jale Cordan, Türel B, Ilcol B, Dilek Yeşilbursa, Serdar A |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı., Yeşilbursa, Dilek, Serdar, Akın, İlçöl, Bülent, Türel, Baybars, Cordan, Jale |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Physical stress
Male Blood pressure regulation Exercise test Blood Pressure Essential hypertension Trial Heart Rate Coughing Priority journal biology General Medicine Middle Aged Blood pressure monitoring Mental stress Hypertension Systolic blood pressure Cardiology Fosinopril Female Cardiology and Cardiovascular Medicine medicine.drug Human Adult medicine.medical_specialty Ambulatory blood pressure Clinical article Prehypertension Article Bruce protocol Internal medicine Diastolic blood pressure Heart rate Dose response Internal Medicine medicine Humans Converting enzyme-inhibition Exercise Antihypertensive Agents business.industry Angiotensin-converting enzyme medicine.disease Surgery Drug effect Drug efficacy Blood pressure Cardiovascular system & cardiology Peripheral vascular disease biology.protein Brain Natriuretic Peptide Microalbuminuria Diabetic Nephropathies business Stress Psychological |
| Popis: | In this study the effects of once daily administration of 10 mg fosinopril on blood pressure response to mental and physical stress were evaluated in mild to moderate essential hypertension. A total of 25 patients (14 women, 9 men) with mild to moderate essential hypertension were enrolled in this study. Before the treatment and after 10 mg/day fosinopril treatment for 2 months, systolic and diastolic blood pressure and heart rate were recorded at rest and while performing a mental arithmetic test. In addition, exercise stress testing with Bruce protocol were performed before and after the treatment and systolic and diastolic blood pressure and heart rate were recorded at rest and during peak exercise. Statistical analysis were done by using the paired t-test. During the mental arithmetic test, systolic and diastolic blood pressure were significantly reduced (p < 0.005 and p < 0.001, respectively) after 2 months fosinopril treatment. Systolic and diastolic blood pressure were also significantly reduced during the exercise stress test (p < 0.005 and p < 0.05) after the treatment. Heart rate did not change during either the mental arithmetic or the exercise test. As a result, once daily 10 mg fosinopril may be effective in reducing blood pressure, not only at rest, but also during stressful situations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|