Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database
| Autor: | Woochul Noh, Se-Heon Cho, Young A Kim, Joon Jeong, Min Ho Park, Ki-Tae Hwang, Jongjin Kim, Hyouk Jin Lee, Sohee Oh, Jonghan Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Multivariate analysis Databases Factual medicine.medical_treatment Breast Neoplasms Education 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine Republic of Korea Medicine Humans 030212 general & internal medicine Registries Neoplasm Metastasis Survival analysis Neoplasm Staging Educational status business.industry Lumpectomy Hazard ratio Confounding Age Factors Middle Aged medicine.disease Prognosis Combined Modality Therapy Confidence interval Tumor Burden Radiation therapy 030220 oncology & carcinogenesis Population Surveillance Original Article Female business Follow-Up Studies |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| Popis: | Purpose This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors. Materials and Methods The data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period; the high EL group (≥ 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups. Results A high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626; 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged ≤ 50 years (hazard ratio, 0.941; 95% CI, 0.865 to 1.024). The EL was a significant independent factor in the subgroup aged > 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer. Conclusion The EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged ≤ 50 years. Favorable clinicopathologic features and active treatments can explain the main causality of the superior prognosis in the high EL group. |
| Databáze: | OpenAIRE |
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