Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients
| Autor: | Rajko Miskulin, Leon Cindrić, Damir Raljević, Viktor Peršić, Elitza Markova-Car, Marta Žuvić, Sandra Kraljević Pavelić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Vitamin
medicine.medical_specialty vitamin D-binding protein Vitamin D-binding protein vitamin D 030204 cardiovascular system & hematology Gastroenterology Pathogenesis Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine myocardium infarction (MI) Internal medicine Genotype medicine Vitamin D and neurology 030212 general & internal medicine Myocardial infarction single nucleotide polymorphism (SNP cardiovascular diseases Genotyping BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina business.industry General Medicine medicine.disease Coronary artery disease (CAD) chemistry single nucleotide polymorphism (SNP) Original Article business |
| Zdroj: | Annals of Translational Medicine Volume 7 Issue 16 |
| ISSN: | 2305-5839 2305-5847 |
| Popis: | Background: Cardiovascular diseases (CVD) are among leading causes of death worldwide and amongst CVD, coronary artery disease (CAD) accounts for almost half of all cardiovascular deaths as the most common cause of death in the developed world. Vitamin D and the vitamin D-binding protein (VDBP) have been studied as possible CAD pathogenesis factors but literature data provide opposing evidence on their role in CAD. Herein we aimed to present novel evidence on the association of two VDBP polymorphisms (rs4588) and (rs7041) with CAD in patients after acute myocardial infarction and study possible correlations of these polymorphisms with 25-hydroxyvitamin D [25(OH)D] serum levels. Methods: The cross-section genotyping study included 155 subjects with CAD upon acute myocardial infarct and 104 control subjects. All patients and control group were Caucasians of European descent. VDBP polymorphisms (rs4588) and (rs7041) were studied by use of RT-PCR. Liquid chromatography, tandem mass spectrometry (LC-MS/MS) method was used for measurement of vitamin D in the serum. Results: Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found. No correlation of 25(OH)D serum levels with CAD were established but the multivariate logistic regression modelling enabled association of total vitamin D level and VDBP (rs4588) T/T genotype with CAD and anteroseptal myocardial infarction (ASMI) CAD occurrence. Conclusions: Obtained data speak in favor to the VDBP (rs4588) T/T genotype as a susceptibility factor for anteroseptal myocardial infarction where the same genotype showed to be generally more prevalent in smokers. |
| Databáze: | OpenAIRE |
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