Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long-term follow-up
| Autor: | Bruno Bergamasco, Alessia Tavella, E Torre, Michele Lanotte, P Perozzo, Mario Giorgio Rizzone, E. Bosticco, Leonardo Lopiano |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Levodopa Dyskinesia Drug-Induced Neurology Parkinson's disease Deep brain stimulation Time Factors medicine.medical_treatment Stimulation Electric Stimulation Therapy Dermatology Antiparkinson Agents Subthalamic Nucleus medicine Humans Aged Dopaminergic Parkinson Disease General Medicine Middle Aged medicine.disease nervous system diseases Surgery Electrodes Implanted Psychiatry and Mental health Subthalamic nucleus surgical procedures operative Treatment Outcome Quality of Life Female Neurology (clinical) Neurosurgery Psychology medicine.drug Follow-Up Studies |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 23 |
| ISSN: | 1590-1874 |
| Popis: | Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective therapy for the treatment of advanced Parkinson's disease (PD). Forty-seven patients were bilaterally implanted for STN DBS and clinically evaluated according to the Core Assessment Program for Intracerebral Transplantations before surgery and 3, 12 and 24 months after surgery. Electrical stimulation led to a significant improvement in motor symptoms and in the quality of life, allowing a significant reduction of dopaminergic drugs with a consequent improvement of drug-induced dyskinesias. Statistical differences were observed between UPDRS parts II, III and IV values and daily levodopa dosage in the pre- and postoperative periods, while no differences were evident between the 3 postoperative conditions. |
| Databáze: | OpenAIRE |
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