Anorectal pruritus after intravenous hydrocortisone sodium succinate and sodium phosphate
| Autor: | A. R. DiSanto, R. D. Stewart, T. J. Gilbertson, E. Novak, C. E. Seckman, S. S. Stubbs |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Side effect Hydrocortisone medicine.medical_treatment Sodium Potassium chemistry.chemical_element Placebo Phosphates Placebos chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Hydrocortisone sodium phosphate Pruritus Ani Saline Pharmacology Succinates Phosphate Endocrinology chemistry Injections Intravenous Hydrocortisone sodium succinate |
| Zdroj: | Clinical pharmacology and therapeutics. 20(1) |
| ISSN: | 0009-9236 |
| Popis: | A double-blind study demonstrated that single intravenous doses of 100, 200, or 400 mg of hydrocortisone sodium succinate and hydrocortisone sodium phosphate were similar in eosinophil suppression, elevation of glucose, white blood count differential shifts (polymorphonuclear cells, lymphocytes, and monocytes), and urinary excretion of sodium and potassium but not in incidence of side effects. More subjects receiving hydrocortisone sodium phosphate experienced systemic or localized adverse effects than those receiving hydrocortisone sodium succinate. The most common side effect was burning or itching in the anorectal area, which occurred in 16 of 18 subjects medicated with hydrocortisone sodium phosphate, in 1 subject of 6 treated with placebo (saline), and in none who received the sodium succinate. The effect is attributed to the phosphate steroid and appears to last as long as it takes to convert to cortisol. |
| Databáze: | OpenAIRE |
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