Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Autor: Catherine Ibisch, Jérôme Abadie, Adelina Gama, F. Nguyen, Anton Belousov, Delphine Loussouarn, Mario Campone, Natascha Rieder, Laura Peña
Přispěvatelé: Animaux Modèles pour la Recherche en Oncologie (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique ( ONIRIS ), Stress Adaptation and Tumor Escape in breast cancer - SATE ( CRCINA - Département ONCO - Equipe 8 ), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers ( CRCINA ), Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ) -Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ), Department of Animal Medicine, Surgery and Pathology [Madrid, Spain], Complutense University of Madrid ( UCM ), Service de Pathologie [CHU Nantes], Centre hospitalier universitaire de Nantes ( CHU Nantes ), Animal and Veterinary Research Centre - CECAV [Vila Real, Portugal], University of Trás-os-Montes and Alto Douro [Portugal] ( UTAD ), Pathology and Tissue Analytics, Pharma Research & Early Development [Munich, Germany], Roche Innovation Center Munich [Germany], Pharmaceutical Sciences, Pharma Research & Early Development [Munich, Germany], Roche Innovation Center Munich [Munich, Germany], UNICANCER - Institut de cancérologie de l'Ouest - Paul Papin [Angers], This work was supported by the French National Cancer Institute (INCa, Institut National du Cancer) with a grant for translational research (INCa-DHOS 2010, Pr M. Campone) and one grant for PhD students on translational research (Grant N°201108, 2011), and by Roche Diagnostics GmbH, Germany, which provided financial and technical support for the immunohistochemical characterization of the carcinomas., Animaux modèles pour la recherche en oncologie comparée (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Stress Adaptation and Tumor Escape in Breast Cancer (CRCINA-ÉQUIPE 8), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Centre hospitalier universitaire de Nantes (CHU Nantes), University of Trás-os-Montes and Alto Douro [Portugal] (UTAD), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Bernardo, Elizabeth, École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Oncology
Cancer Research
Proliferation index
Receptor
ErbB-2
Lymphovascular invasion
medicine.medical_treatment
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
0403 veterinary science
Preclinical Study
0302 clinical medicine
Breast cancer
Dog
Medicine
Epidermal growth factor receptor
Mastectomy
biology
Spontaneous animal model
04 agricultural and veterinary sciences
Prognosis
3. Good health
Receptors
Estrogen
030220 oncology & carcinogenesis
Female
Receptors
Progesterone
medicine.medical_specialty
040301 veterinary sciences
[SDV.CAN]Life Sciences [q-bio]/Cancer
Breast Neoplasms
Mammary Neoplasms
Animal
03 medical and health sciences
Dogs
[SDV.CAN] Life Sciences [q-bio]/Cancer
Internal medicine
HER2
Progesterone receptor
Animals
Humans
Neoplasm Invasiveness
business.industry
Estrogen Receptor alpha
Cancer
medicine.disease
Disease Models
Animal
Multivariate Analysis
biology.protein
business
Estrogen receptor alpha
Zdroj: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2017, Epub ahead of print. 〈10.1007/s10549-017-4548-2〉
Breast Cancer Research and Treatment, Springer Verlag, 2017, Epub ahead of print. ⟨10.1007/s10549-017-4548-2⟩
Breast Cancer Research and Treatment, 2017, Epub ahead of print. ⟨10.1007/s10549-017-4548-2⟩
ISSN: 0167-6806
1573-7217
DOI: 10.1007/s10549-017-4548-2〉
Popis: International audience; PURPOSE:Dogs have been proposed as spontaneous animal models of human breast cancer, based on clinicopathologic similarities between canine and human mammary carcinomas. We hypothesized that a better knowledge of the natural history and prognostic factors of canine invasive mammary carcinomas would favor the design of preclinical trials using dogs as models of breast cancer.METHODS:The 2-year outcome of 350 female dogs with spontaneous invasive mammary carcinoma was studied. The investigated prognostic factors included age at diagnosis, pathologic tumor size, pathologic nodal stage, lymphovascular invasion, histological grade, and expression of Estrogen Receptor alpha (ERα), Progesterone Receptor, Ki-67, Human Epidermal Growth Factor Receptor 2, basal cytokeratins 5/6, and Epidermal Growth Factor Receptor. Multivariate survival analyses were performed using the Cox proportional hazards model.RESULTS:The overall survival after mastectomy was 11 months. Within 1 year post mastectomy, 41.5% of dogs (145/350) died from their mammary carcinoma. By multivariate analysis, the significant prognostic factors for overall survival included a pathologic tumor size larger than 20 mm [HR 1.47 (95% confidence interval 1.15-1.89)], a positive nodal stage [pN+, HR 1.89 (1.43-2.48)], a histological grade III [HR 1.32 (1.02-1.69)], ERα negativity [HR 1.39 (1.01-1.89)], a high Ki-67 proliferation index [HR 1.32 (1.04-1.67)], and EGFR absence [HR 1.33 (1.04-1.69)].CONCLUSION:The short natural history of spontaneous canine invasive mammary carcinomas and high rate of cancer-related death allow for rapid termination of preclinical investigations. The prognostic factors of invasive mammary carcinomas are remarkably similar in dogs and humans, highlighting the similarities in cancer biology between both species.
Databáze: OpenAIRE
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