Effect of Ascorbic Acid (Vitamin C) on the Epiphyseal Plate of Young Guinea Pigs Receiving Prednisolone
| Autor: | N L Doulas, Vlachos P, D Liakakos, Alexiou D, Litsios B |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Vitamin C business.industry Prednisolone Epiphyseal plate Guinea Pigs Ascorbic Acid Ascorbic acid Endocrinology medicine.anatomical_structure Internal medicine medicine Animals Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics business Epiphyses Prolonged treatment medicine.drug |
| Zdroj: | Developmental Pharmacology and Therapeutics. 2:69-79 |
| ISSN: | 2504-2505 0379-8305 |
| DOI: | 10.1159/000481033 |
| Popis: | The effect of excess ascorbic acid on the epiphyseal plate of young guinea pigs receiving prednisolone over a period of 28 days has been investigated. The results show that the structural and morphologic changes caused in the epiphyseal plate of the animals receiving prednisolone are prevented by the simultaneous administration of excess ascorbic acid. These data are consistent with the hypothesis that pharmacological doses of ascorbic acid given concurrently to children receiving prolonged treatment with corticosteroids may prevent suppression of growth in these children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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