Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study
| Autor: | Deborah K. Froh, Martyn Botfield, Sean B. Fain, Jaime F. Mata, Craig H. Meyer, Mac Johnson, John P. Mugler, Alix Paget-Brown, Kai Ruppert, Talissa A. Altes, Eduard E. de Lange, W. Gerald Teague |
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| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
Male medicine.medical_specialty Hyperpolarized Helium 3 Helium Proof of Concept Study 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Isotopes Lung imaging medicine Humans Radiology Nuclear Medicine and imaging In patient Respiratory system Lung medicine.diagnostic_test business.industry Infant Reproducibility of Results Magnetic resonance imaging respiratory system Magnetic Resonance Imaging Young age 030228 respiratory system Lung disease Child Preschool Breathing Female Radiology business |
| Zdroj: | Clinical Imaging. 45:105-110 |
| ISSN: | 0899-7071 |
| Popis: | Purpose To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. Materials and methods HHe ventilation MRI was performed on seven children ≤ 4 years old. Contiguous 2D–spiral helium-3 images were acquired sequentially with a scan time of ≤ 0.2 s/slice. Results Motion-artifact–free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. Conclusion HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age. |
| Databáze: | OpenAIRE |
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