Are vitamin D and vitamin D receptor levels different in children with developmental dysplasia of the hip?
| Autor: | Ali Aydın Karadeniz, Fatih Doğar, Burak Tanriverdi, Muhammet Seyithanoğlu, Fırat Ozan, Ökkeş Bilal, Duran Topak |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Vitamin musculoskeletal diseases medicine.medical_specialty lcsh:Diseases of the musculoskeletal system chemistry.chemical_element Calcium Calcitriol receptor Genetic transmission 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Orthopedic surgery Internal medicine Vitamin D and neurology medicine Humans Orthopedics and Sports Medicine 030212 general & internal medicine Risk factor Vitamin D Child Developmental dysplasia business.industry Infant lcsh:RD701-811 Endocrinology chemistry Vitamin D receptor Child Preschool Receptors Calcitriol Alkaline phosphatase Female Surgery lcsh:RC925-935 business 030217 neurology & neurosurgery Research Article Developmental dysplasia of the hip |
| Zdroj: | Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-5 (2021) Journal of Orthopaedic Surgery and Research |
| Popis: | Introduction Developmental dysplasia of the hip (DDH) is a common disorder and associated with significant morbidity of the hip joint. Several risk factors have been identified for DDH. The aim of this study is to investigate whether vitamin D and vitamin D receptor (VDR) levels differ in children with DDH and whether they have an effect on DDH development. Materials and methods A total of 40 (17 males, 23 females; 9 right hips, 16 left hips, 15 bilateral hips) children who were treated for developmental dysplasia and 40 (23 males, 17 females) healthy children without any musculoskeletal system and metabolic disorders were included in this study between January and June 2019. Blood samples from the DDH and control groups of children were collected to measure the serum levels of vitamin D, VDR, calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP). The levels of Ca, P, and ALP were analyzed using the automated standard spectrophotometric laboratory method. The levels of vitamin D and VDR in the samples were analyzed using enzyme-linked immunoassay. Results There were no significant differences in the serum levels of Ca, P, ALP, and vitamin D between the DDH and healthy groups (Ca 9.96 ± 0.47 vs. 9.92 ± 0.48 mg/dL, respectively, p = 0.721; P 5.3 ± 0.94 vs. 4.82 ± 0.88 mg/dL, respectively, p = 0.23; ALP 252.22 ± 170.15 vs. 245.3 ± 130.93 U/L, respectively, p = 0.839). However, serum VDR levels were significantly lower in children in the DDH group (5.77 ± 3.51 ng/mL) than in the healthy control group (9.25 ± 6.43 ng/mL) (p = 0.004). Conclusions In conclusion, we believe that low VDR levels can affect DDH regardless of the serum levels of Ca, P, ALP, and vitamin D. More comprehensive studies involving parents are needed to understand whether VDR levels mediate genetic transmission in DDH or not. |
| Databáze: | OpenAIRE |
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