Cardiovascular adaptation to the Fontan circulation
| Autor: | Daniel J. Penny, Alexander R. Opotowsky, Gruschen R. Veldtman, Bradley S. Marino, Marc Gewillig, Samuel G. Wittekind, Mark A. Fogel, Jack Rychik |
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| Rok vydání: | 2017 |
| Předmět: |
Heart Defects
Congenital medicine.medical_specialty 030204 cardiovascular system & hematology Fontan Procedure Fontan circulation Microcirculation Cardiovascular Physiological Phenomena 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Intensive care medicine business.industry General Medicine Key features Adaptation Physiological Fontan operations medicine.anatomical_structure Ventricle Pediatrics Perinatology and Child Health Circulatory system Cardiology Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | Congenital Heart Disease. 12:699-710 |
| ISSN: | 1747-079X |
| DOI: | 10.1111/chd.12526 |
| Popis: | Although medium-term survival following Fontan operations in the modern era has improved dramatically, late cardiovascular and extracardiac morbidity are common and are associated with impaired quality of life and premature late mortality. This serves as a reminder of the extraordinary adaptations required of the cardiovascular system when the systemic arterial, systemic venous and pulmonary circulations are placed in series coupled to a single ventricular pump. This article reviews the key features and principles that govern interactions between the ventricle, systemic arterial circulation, the systemic venous and pulmonary circulatory compartments, the microcirculation, and lymphatic circulations. The overarching aim is to provide insight into the integrative pathophysiology that governs the Fontan circulation and stimulate thoughtful approaches to advance research. |
| Databáze: | OpenAIRE |
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