N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase
| Autor: | Thomas Boesen, Anders Hallberg, Hans-Erik Claesson, Benjamin Pelcman, Wesley Schaal, Christian Krog-Jensen, Pontus Forsell, Mats Larhed, Hasse Kromann, Kristofer Olofsson, Andrei Sanin, Peter M. Nilsson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
biology
Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Pyrazole Amides Biochemistry chemistry.chemical_compound Lipoxygenase chemistry Drug Discovery biology.protein Arachidonate 15-Lipoxygenase Humans Pyrazoles Molecular Medicine Arachidonic acid Lipoxygenase Inhibitors Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:3017-3023 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2015.05.007 |
| Popis: | High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect