Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women
| Autor: | Theresa Moriarty, Heather Devore, Samuel J. Simmens, Brendan Capozzi, Christopher Joy, Afsoon D. Roberts, Mariel Jais, Kaleigh Connors, Hani Mohamed, Annette Aldous, Gary L. Simon, Maria Zumer, Monika Juzumaite, Jason Daniels, Manya Magnus, Mimi Ghosh, Catherine Hatch Schultz |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Chemokine Adolescent medicine.medical_treatment media_common.quotation_subject Immunology Physiology Inflammation HIV Infections Pilot Projects medicine.disease_cause Pathogenesis 03 medical and health sciences Young Adult 0302 clinical medicine Immune system Acquired immunodeficiency syndrome (AIDS) medicine Immunology and Allergy Humans Menstrual cycle media_common 030219 obstetrics & reproductive medicine biology business.industry Sex Offenses Obstetrics and Gynecology Immune dysregulation Middle Aged medicine.disease 030104 developmental biology Cytokine Cross-Sectional Studies Reproductive Medicine biology.protein Female Disease Susceptibility medicine.symptom business Biomarkers |
| Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989)REFERENCES. 86(3) |
| ISSN: | 1600-0897 |
| Popis: | PROBLEM HIV/AIDS and sexual violence act synergistically and compromise women's health. Yet, immuno-biological mechanisms linking sexual violence and increased HIV susceptibility are poorly understood. METHODS We conducted a cross-sectional pilot study of HIV-uninfected women, comparing 13 women exposed to forced vaginal penetration within the past 12 weeks (Exposed) with 25 Non-Exposed women. ELISA assays were conducted for 49 biomarkers associated with HIV pathogenesis in plasma and cervicovaginal lavage (CVL). Differences between Exposed and Non-Exposed were analyzed by linear and logistic regression, using propensity score weighting to control for age, race, socioeconomic status, menstrual cycle, and contraceptive use. RESULTS In CVL, Exposed women had significantly reduced chemokines MIP-3α (p |
| Databáze: | OpenAIRE |
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