Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Autor: Houlston, Richard S, Cheadle, Jeremy, Dobbins, Sara E, Tenesa, Albert, Jones, Angela M, Howarth, Kimberley, Spain, Sarah L, Broderick, Peter, Domingo, Enric, Farrington, Susan, Prendergast, James GD, Pittman, Alan M, Theodoratou, Evi, Smith, Christopher G, Olver, Bianca, Walther, Axel, Barnetson, Rebecca A, Churchman, Michael, Jaeger, Emma EM, Penegar, Steven, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Mager, Rachel, Johnstone, Elaine, Midgley, Rachel, Niittymäki, Iina, Tuupanen, Sari, Colley, James, Idziaszczyk, Shelley, COGENT Consortium, Thomas, Huw JW, Lucassen, Anneke M, Evans, D Gareth R, Maher, Eamonn R, CORGI Consortium, COIN Collaborative Group, COINB Collaborative Group, Maughan, Timothy, Dimas, Antigone, Dermitzakis, Emmanouil, Cazier, Jean-Baptiste, Aaltonen, Lauri A, Pharoah, Paul, Kerr, David J, Carvajal-Carmona, Luis G, Campbell, Harry, Dunlop, Malcolm G, Tomlinson, Ian PM
Rok vydání: 2010
Předmět:
Male
Genome-wide association study
Medical and Health Sciences
0302 clinical medicine
Genotype
Odds Ratio
Pair 12
ddc:576.5
Pair 13
Cancer
Oligonucleotide Array Sequence Analysis
Genetics
0303 health sciences
Chromosome Mapping
Single Nucleotide
Biological Sciences
Chromosomes
Human
Pair 3/*genetics
Colo-Rectal Cancer
3. Good health
CORGI Consortium
Chromosomes
Human
Pair 1
030220 oncology & carcinogenesis
Meta-analysis
Pair 3
COINB Collaborative Group
Pair 1
Female
Chromosomes
Human
Pair 3
Colorectal Neoplasms
Human
Locus (genetics)
Single-nucleotide polymorphism
Biology
Polymorphism
Single Nucleotide
Risk Assessment
Article
Chromosomes
03 medical and health sciences
Genome-Wide Association Study/methods
Meta-Analysis as Topic
medicine
Humans
Genetic Predisposition to Disease
Chromosomes
Human
Pair 12/*genetics
Polymorphism
030304 developmental biology
Genetic association
COIN Collaborative Group
Colorectal Neoplasms/*genetics
Chromosomes
Human
Pair 12
Chromosomes
Human
Pair 13
Prevention
Human Genome
COGENT Consortium
Odds ratio
medicine.disease
Chromosomes
Human
Pair 1/*genetics
Chromosome Mapping/methods
Chromosomes
Human
Pair 13/*genetics
Digestive Diseases
Genome-Wide Association Study
Developmental Biology
Zdroj: Nature genetics, vol 42, iss 11
Houlston, R S, Cheadle, J, Dobbins, S E, Tenesa, A, Jones, A M, Howarth, K, Spain, S L, Broderick, P, Domingo, E, Farrington, S, Prendergast, J, Pittman, A M, Theodoratou, E, Smith, C G, Olver, B, Walther, A, Barnetson, R A, Churchman, M, Jaeger, E E M, Penegar, S, Barclay, E, Martin, L, Gorman, M, Mager, R, Johnstone, E, Midgley, R, Niittymäki, I, Tuupanen, S, Colley, J, Idziaszczyk, S, Thomas, H J W, Lucassen, A M, Evans, D G R, Maher, E R, Maughan, T, Dimas, A, Dermitzakis, E, Cazier, J-B, Aaltonen, L A, Pharoah, P, Kerr, D J, Carvajal-Carmona, L G, Campbell, H & Dunlop, M G & Tomlinson, I P M 2010, ' Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 ', Nature Genetics, vol. 42, no. 11, pp. 973-979 . https://doi.org/10.1038/ng.670
Nature genetics
Nature Genetics, Vol. 42, No 11 (2010) pp. 973-977
ISSN: 1093-6599
1061-4036
DOI: 10.1038/ng.670
Popis: Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55-10-10 and rs6687758, OR = 1.09, P = 2.27-10-9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39-10-8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89-10-10 and rs7136702, OR = 1.06, P = 4.02-10 -8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89-10-10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. © 2010 Nature America, Inc. All rights reserved.
Databáze: OpenAIRE
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