Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
| Autor: | Camila Mareti Bonin, Ana Flávia Silva Pina, Inês Aparecida Tozetti, Márcia Maria Ferrairo Janini Dal Fabbro, Vanessa Terezinha Gubert de Matos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult CD4-Positive T-Lymphocytes Cytokine profile lcsh:QR1-502 HIV Infections CD8-Positive T-Lymphocytes lcsh:Microbiology HIV Long-Term Survivors lcsh:Infectious and parasitic diseases 03 medical and health sciences Immune system Th2 Cells Hiv infected Antiretroviral Therapy Highly Active Medicine Infection control Humans lcsh:RC109-216 Immunity Cellular business.industry Interleukin Th1 Cells Viral Load Antiretroviral therapy 030104 developmental biology Infectious Diseases Immunology HIV-1 Cytokines Female business Elite controllers Viral load |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 22, Iss 2, Pp 142-145 (2018) |
| ISSN: | 1413-8670 |
| Popis: | The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles. Keywords: Interleukins, HIV seropositivity, Disease progression, Antiretroviral therapy |
| Databáze: | OpenAIRE |
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