Angiocentric cutaneous T-cell lymphoma of childhood (hydroa-like lymphoma): A distinctive type of cutaneous T-cell lymphoma
| Autor: | Mario Magaña, Pastor Sangueza, Sergio Sánchez-Sosa, Omar P. Sangueza, Angeles Salgado, Javier Gil-Beristain, Guillermo Ramón |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Herpesvirus 4 Human Pathology medicine.medical_specialty Skin Neoplasms CD30 Dermatology Virus Pathogenesis hemic and lymphatic diseases medicine Humans Child In Situ Hybridization Skin business.industry Cutaneous T-cell lymphoma Herpesviridae Infections medicine.disease Lymphoma T-Cell Cutaneous Lymphoma Tumor Virus Infections Child Preschool Hydroa vacciniforme Immunohistochemistry Panniculitis business |
| Zdroj: | Journal of the American Academy of Dermatology. 38:574-579 |
| ISSN: | 0190-9622 |
| Popis: | Background: Angiocentric cutaneous T-cell lymphomas of childhood (ACTCLC) are an unusual type of T-cell lymphomas that present with a vesiculopapular eruption mimicking hydroa vacciniforme. Most patients have been children from Asia and Latin America. Objective: The purpose of this study was to describe four cases of ACTCLC; to discuss its clinical, histopathologic, and immunohistochemical features; to consider its possible relationship to the Epstein-Barr virus (EBV); and to clarify its classification within the spectrum of angiocentric lymphomas. Methods: The clinical, histopathologic, and immunohistochemical features of four cases of ACTCLC were identified and analyzed. In addition in situ hybridization for EBV was performed in all cases. Results: The clinical features were similar to previous cases reported under different names, such as hydroa-like lymphomas, edematous, scarring vasculitic panniculitis. Histologically, all showed angiocentric infiltrates composed mainly of T cells. In all cases there were variable numbers of CD30+ cells. The EBV was present in three of the cases. Conclusion: ACTCLC is a distinct type of T-cell lymphoma. It affects mainly children, and the EBV appears to play a role in the pathogenesis of this disease. (J Am Acad Dermatol 1998;38:574-9.) |
| Databáze: | OpenAIRE |
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