A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes
| Autor: | Mohammed Alotiby, B.P.E. Tee, David Bolst, D. H. Wright, Samer Bakr, Vladimir Ivanchenko, Tibor Kibedi, Anatoly B. Rosenfeld, Sebastien Incerti, Maarten Vos, Laurent Desorgher, Susanna Guatelli, A. Mantero |
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| Přispěvatelé: | Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Monte Carlo method Brachytherapy Reference data (financial markets) Electrons Radiation 010403 inorganic & nuclear chemistry 01 natural sciences 030218 nuclear medicine & medical imaging Auger 03 medical and health sciences symbols.namesake 0302 clinical medicine medicine ComputingMilieux_MISCELLANEOUS Physics Auger electron spectroscopy Auger effect 3. Good health 0104 chemical sciences Computational physics Benchmarking symbols [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Radiopharmaceuticals Monte Carlo Method Radioactive decay |
| Zdroj: | Applied Radiation and Isotopes Applied Radiation and Isotopes, Elsevier, 2021, 174, pp.109777. ⟨10.1016/j.apradiso.2021.109777⟩ |
| ISSN: | 0969-8043 |
| Popis: | Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of 123I, 124I, 125I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of 131Cs, which is of interest for brachytherapy. In the case of 125I and 131Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications. |
| Databáze: | OpenAIRE |
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