A Rare Alder‐ene Cycloisomerization of 1,6‐Allenynes
| Autor: | Liam M. Joyce, Melanie A. Drew, Andrew J. Tague, Thanaphat Thaima, Ali Gouranourimi, Alireza Ariafard, Stephen G. Pyne, Christopher J. T. Hyland |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chemistry – A European Journal. 28 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/chem.202104022 |
| Popis: | Thermally induced cycloisomerization reactions of 1,6-allenynes gives α-methylene-γ-lactams via intramolecular Alder-ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non-radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold. |
| Databáze: | OpenAIRE |
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