SEVERE MALARIA AND GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY: A REAPPRAISAL OF THE MALARIA/G-6-P.D. HYPOTHESIS
| Autor: | B.O Osunkoya, D Alling, G.J.F Esan, M Deane, V.C Okoye, LouisH. Miller, S.K Martin |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Genotype Plasmodium falciparum Nigeria Glucosephosphate Dehydrogenase Plasmodium chemistry.chemical_compound Sex Factors parasitic diseases medicine Humans Glucose-6-phosphate dehydrogenase Severe Malaria Selection Genetic Child Polymorphism Genetic biology Glucosephosphates General Medicine medicine.disease biology.organism_classification Malaria Glucosephosphate Dehydrogenase Deficiency chemistry Clinical evidence Child Preschool Immunology Female Glucose-6-phosphate dehydrogenase deficiency |
| Zdroj: | The Lancet. 313:524-526 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(79)90946-2 |
| Popis: | Nigerian children with convulsions and Plasmodium falciparium parasitaemia above 100,000/microliter did not show a decreased frequency of glucose-6-phosphate-dehydrogenase (G.-6-P.D.) deficiency. A re-evaluation of earlier studies has led to the conclusion that clinical evidence of protection against falciparum malaria in G.-6-P.D.-deficient individuals is lacking. Evidence for the possible role of malaria in selecting for G.-6-P.D.-deficient genes consists solely of the geographical association of high frequencies of G.-6-P.D. deficiency with endemic malaria. |
| Databáze: | OpenAIRE |
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