Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature
| Autor: | Andreas A. Argyriou, Ioanna Chalimou, Antonios Krilis, Alexandra Makridou, Nicolaos Makris, Michael Vikelis, Garifallia G Anastopoulou, Heike Braun |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 03 medical and health sciences Young Adult 0302 clinical medicine Acne Vulgaris medicine Humans Meningitis Aseptic skin and connective tissue diseases Isotretinoin business.industry General Neuroscience Headache Aseptic meningitis General Medicine medicine.disease Dermatology 030104 developmental biology Female Nodular acne business 030217 neurology & neurosurgery Adverse drug reaction medicine.drug |
| Zdroj: | The International journal of neuroscience. 129(2) |
| ISSN: | 1563-5279 |
| Popis: | Purpose/aim: We describe, in detail, the first case of isotretinoin-induced aseptic meningitis. A brief summary of the literature on drug-induced aseptic meningitis (DIAM) is also presented.A 20-year old female patient with probable (Naranjo adverse reaction probability score of 7) DIAM during treatment with isotretinoin therapy for nodular acne solely, presenting with headache. Pseudotumor cerebri was appropriately ruled-out.Summary of data altogether lead us suggest that isotretinoin triggered DIAM, possible due to a delayed hypersensitivity mechanism type III or IV.We highlight a quite uncommon cause of DIAM that may be increasing in frequency due to the current increasing use of isotretinoin against nodular acne. |
| Databáze: | OpenAIRE |
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