Orally and transdermally replaced estradiol improves endothelial function equally in middle-aged women after surgical menopause
| Autor: | Miran Sebestjen, Elko Borko, Irena Keber, Branka Žegura |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Brachial Artery medicine.drug_class Administration Sublingual Administration Oral Blood lipids Antineoplastic Agents Hyperemia Administration Cutaneous Hysterectomy Nitroglycerin Route of administration Adnexa Uteri Double-Blind Method Oral administration Internal medicine medicine.artery Humans Medicine Brachial artery Reactive hyperemia Ultrasonography Transdermal Estradiol business.industry Obstetrics and Gynecology Middle Aged Prognosis medicine.disease Lipids Vasodilation Menopause Endocrinology Regional Blood Flow Estrogen Female Endothelium Vascular business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 188:1291-1296 |
| ISSN: | 0002-9378 |
| DOI: | 10.1067/mob.2003.326 |
| Popis: | Objective: Improvement in endothelial function may be an important mechanism by which estrogen replacement therapy protects postmenopausal women against coronary artery disease. We determined whether the vascular effects of estradiol depend on the route of administration. Study Design: Six weeks after surgically induced menopause, 43 healthy women were assigned randomly to 28 weeks of treatment by either orally or transdermally replaced estradiol. Endothelium-dependent and endothelium-independent dilation were calculated with the use of the diameters of the brachial artery that were measured at rest by high resolution ultrasound scanning after reactive hyperemia and after sublingual glyceryl trinitrate. Results: Endothelium-dependent dilation increased after oral estradiol replacement from 6% ± 3.9% to 13.2% ± 4.4% (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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