Increase in the ability of human cancer cells to induce cytotoxic T lymphocytes by ultraviolet irradiation
Autor: | Omar Eton, K. Hayakawa, Lazel B. Augustus, Merric I. Ross, Dai Seito, Kyogo Itoh, David A. Swanson, Yasuiki Umezu |
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Rok vydání: | 1993 |
Předmět: |
Cytotoxicity
Immunologic Cancer Research Ultraviolet Rays medicine.medical_treatment Immunology chemical and pharmacologic phenomena Lymphocyte Activation Peripheral blood mononuclear cell Interferon-gamma Lymphocytes Tumor-Infiltrating MHC class I medicine Tumor Cells Cultured Immunology and Allergy Cytotoxic T cell Humans Carcinoma Renal Cell Melanoma biology Histocompatibility Antigens Class I Histocompatibility Antigens Class II hemic and immune systems Immunotherapy T lymphocyte Kidney Neoplasms Isolated Tumor Cells CTL Oncology biology.protein Cancer research Clone (B-cell biology) T-Lymphocytes Cytotoxic |
Zdroj: | Cancer immunology, immunotherapy : CII. 37(6) |
ISSN: | 0340-7004 |
Popis: | The roles of ultraviolet-B (UV) radiation in the immunogenicity of human cancer cells have not been fully studied. We have investigated the effects of UV radiation on metastatic melanoma and renal cell carcinoma cells with regard to MHC antigen expression and the ability to induce cytotoxic T lymphocyte (CTL) activity in peripheral blood mononuclear cells (PBMC) or tumor-infiltrating lymphocytes (TIL) against untreated autologous tumor cells. UV radiation respectively decreased or increased MHC class I expression of freshly isolated tumor cells or cultured tumor cells, and also decreased MHC class I expression of starved cultured tumor cells. It increased the ability of both freshly isolated and cultured tumor cells to induce CTL activity from PBMC against untreated autologous tumor cells. UV-irradiated subclones that were more susceptible to CTL lysis were more potent for CTL induction from TIL than either an untreated parental clone or a UV-irradiated subclone that was resistant to CTL lysis. In summary, UV radiation increased the ability of tumor cells to induce CTL activity without a corresponding effect on MHC antigen expression. |
Databáze: | OpenAIRE |
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