Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury
| Autor: | Tian-Qin Xiong, Qi Wang, Chuan-Lan Sang, Xin-Yue Wang, Shuhuan Fang, Cong Yang, Yunxia Luo, Yujie Huang, Yongbin Zhang, Jiangang Shen, Jiansong Fang, Jun Wu |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug target Gene Expression Traditional Chinese medicine Bioinformatics 03 medical and health sciences Drug Discovery Humans Medicine Liver damage Medical prescription Pharmacology Liver injury business.industry Liver Diseases General Medicine medicine.disease Oxidative Stress 030104 developmental biology Multilevel data Liver Complementary and alternative medicine Hepatocytes business Drugs Chinese Herbal Systems pharmacology |
| Zdroj: | Chinese Journal of Natural Medicines. 16:756-765 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(18)30115-8 |
| Popis: | Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view, in the present study, a systems pharmacology approach was developed, which involved drug target identification and multilevel data integration analysis. Using a comprehensive systems approach, we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets. We further deciphered the mechanisms of SWGJP in treating liver injury, including compound-target network analysis, target-function network analysis, and integrated pathways analysis. We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway, such as Nrf2-dependent anti-oxidative stress module. Notably, systems pharmacology provides an alternative way to investigate the complex action mode of TCM. |
| Databáze: | OpenAIRE |
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