Slc:Wistar/ST rats develop unilateral thyroid dysgenesis: A novel animal model of thyroid hemiagenesis
Autor: | Yaser Hosny Ali Elewa, Osamu Ichii, Yuji Sunden, Tomoji Yoshiyasu, Hideki Hattori, Yasuhiro Kon, Teppei Nakamura, Ken-ichi Nagasaki, Osamu Tatsumi |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Parathyroid endocrine system diseases Peptide Hormones Respiratory System Biochemistry 0302 clinical medicine Medicine and Health Sciences Medicine Enzyme-Linked Immunoassays Thyroid Multidisciplinary Triiodothyronine Age Factors Arteries Animal Models Immunohistochemistry Trachea medicine.anatomical_structure Experimental Organism Systems 030220 oncology & carcinogenesis Thyroid Dysgenesis Female Anatomy Research Article medicine.medical_specialty endocrine system Thyroid Hormones Science Endocrine System Mouse Models Research and Analysis Methods Thyroid dysgenesis Models Biological 03 medical and health sciences Dysgenesis Model Organisms Thyroid-stimulating hormone Internal medicine Ultimopharyngeal body Animals Rats Wistar Thyroid-Stimulating Hormone Immunoassays business.industry Thyroid Artery Biology and Life Sciences medicine.disease Hormones Rats Disease Models Animal 030104 developmental biology Endocrinology Cardiovascular Anatomy Immunologic Techniques Animal Studies Blood Vessels business Hormone |
Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 8, p e0221939 (2019) |
ISSN: | 1932-6203 |
Popis: | Developmental anomalies of the thyroid gland lead to congenital malformations such as thyroglossal duct cysts and thyroid dysgenesis. However, the pathogenesis of thyroid dysgenesis remains unclear due to the lack of suitable animal models. This study demonstrated that Slc:Wistar/ST rats frequently developed unilateral thyroid dysgenesis, including hemiagenesis, characterized by the absence of one lobe. In Wistar/ST rats, each thyroid lobe was frequently different in size, and approximately 27% and 20% of the rats presented with hemihypoplasia and hemiagenesis of the thyroid gland, respectively. Dysgenesis was predominant on the left side in both sexes, without sex differences. At a young age, thyroid hemiagenesis did not alter body weight. In rats of both sexes with thyroid hemiagenesis, plasma total triiodothyronine and total triiodothyronine levels remained unchanged while plasma thyroid-stimulating hormone levels were significantly elevated in young rats. The remaining thyroid lobes increased in weight, but the follicular epithelial cells appeared normal in terms of their height and proliferating activities. On the side of thyroid dysgenesis, the parathyroid glands were normally localized and were situated at the same location as the contralateral glands. The ultimobranchial body remnants were localized at the level of the thyroid gland along with the cranial thyroid artery and vein, forming cell clusters or cystic structures and containing calcitonin-positive C-cells. In conclusion, Wistar/ST rats developed unilateral thyroid dysgenesis and may be novel and useful animal models for thyroid hemiagenesis in humans and for morphogenesis of pharyngeal pouch-derived organs. |
Databáze: | OpenAIRE |
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