Slc:Wistar/ST rats develop unilateral thyroid dysgenesis: A novel animal model of thyroid hemiagenesis

Autor: Yaser Hosny Ali Elewa, Osamu Ichii, Yuji Sunden, Tomoji Yoshiyasu, Hideki Hattori, Yasuhiro Kon, Teppei Nakamura, Ken-ichi Nagasaki, Osamu Tatsumi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Parathyroid
endocrine system diseases
Peptide Hormones
Respiratory System
Biochemistry
0302 clinical medicine
Medicine and Health Sciences
Medicine
Enzyme-Linked Immunoassays
Thyroid
Multidisciplinary
Triiodothyronine
Age Factors
Arteries
Animal Models
Immunohistochemistry
Trachea
medicine.anatomical_structure
Experimental Organism Systems
030220 oncology & carcinogenesis
Thyroid Dysgenesis
Female
Anatomy
Research Article
medicine.medical_specialty
endocrine system
Thyroid Hormones
Science
Endocrine System
Mouse Models
Research and Analysis Methods
Thyroid dysgenesis
Models
Biological
03 medical and health sciences
Dysgenesis
Model Organisms
Thyroid-stimulating hormone
Internal medicine
Ultimopharyngeal body
Animals
Rats
Wistar
Thyroid-Stimulating Hormone
Immunoassays
business.industry
Thyroid Artery
Biology and Life Sciences
medicine.disease
Hormones
Rats
Disease Models
Animal
030104 developmental biology
Endocrinology
Cardiovascular Anatomy
Immunologic Techniques
Animal Studies
Blood Vessels
business
Hormone
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0221939 (2019)
ISSN: 1932-6203
Popis: Developmental anomalies of the thyroid gland lead to congenital malformations such as thyroglossal duct cysts and thyroid dysgenesis. However, the pathogenesis of thyroid dysgenesis remains unclear due to the lack of suitable animal models. This study demonstrated that Slc:Wistar/ST rats frequently developed unilateral thyroid dysgenesis, including hemiagenesis, characterized by the absence of one lobe. In Wistar/ST rats, each thyroid lobe was frequently different in size, and approximately 27% and 20% of the rats presented with hemihypoplasia and hemiagenesis of the thyroid gland, respectively. Dysgenesis was predominant on the left side in both sexes, without sex differences. At a young age, thyroid hemiagenesis did not alter body weight. In rats of both sexes with thyroid hemiagenesis, plasma total triiodothyronine and total triiodothyronine levels remained unchanged while plasma thyroid-stimulating hormone levels were significantly elevated in young rats. The remaining thyroid lobes increased in weight, but the follicular epithelial cells appeared normal in terms of their height and proliferating activities. On the side of thyroid dysgenesis, the parathyroid glands were normally localized and were situated at the same location as the contralateral glands. The ultimobranchial body remnants were localized at the level of the thyroid gland along with the cranial thyroid artery and vein, forming cell clusters or cystic structures and containing calcitonin-positive C-cells. In conclusion, Wistar/ST rats developed unilateral thyroid dysgenesis and may be novel and useful animal models for thyroid hemiagenesis in humans and for morphogenesis of pharyngeal pouch-derived organs.
Databáze: OpenAIRE
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