Femoral Bowing and Femoral Neck-Shaft Angle Evaluation Can Reduce Atypical Femoral Fractures in Osteoporotic Patients: A Scientific Report
| Autor: | Ioannis Papaioannou, Andreas Baikousis, Panagiotis Korovessis, Georgia Pantazidou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
femoral bowing Population 030204 cardiovascular system & hematology urologic and male genital diseases Bone remodeling 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine atypical femoral fractures education femoral neck-shaft angle bisphosphonates Femoral neck education.field_of_study business.industry General Engineering Endocrinology/Diabetes/Metabolism Drug holiday Surgery medicine.anatomical_structure Orthopedics Femoral bowing Cortical bone Public Health Complication business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Bisphosphonates (BPs) are the mainstay of osteoporosis treatment due to their safety and efficacy. There is evidence that BPs medication may be complicated by atypical femoral fractures (AFFs). Prolonged administration of BPs is even more strongly associated with AFFs. AFF is a relatively rare complication of BPs when taking into account the huge population worldwide that benefits from this pharmacotherapy. AFF is, however, a serious complication of BPs treatment, which includes prolonged healing time and high revision rate when operative treatment is required. Less frequently, AFFs occur even without BPs administration, while these fractures have all the characteristics of "stress" or "insufficiency" fractures. The critical point of view in AFFs pathogenesis seems to be not only the biology of cortical bone, but also the mechanical issue. It has been proven that BPs, glucocorticoids and proton pump inhibitors (PPIs) can cause bone turnover suppression and affect the biological parameter of AFFs pathogenesis. Specific mechanical femoral bone properties predispose to AFFs pathogenesis. Several studies have already reported that increased femoral bowing > 5.250 degrees or decreased femoral neck-shaft angle |
| Databáze: | OpenAIRE |
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